News &amp; Updates

Children with homozygous familial hypercholesterolaemia (HoFH) achieve significant and clinically meaningful reductions in low-density lipoprotein cholesterol (LDL-C) with the microsomal triglyceride transfer protein (MTP) inhibitor lomitapide, which represents an efficient LDL receptor-independent treatment option, according to the open-label phase III APH-19 trial.

Lomitapide lowers LDL-C levels in paediatric homozygous familial hypercholesterolaemia

Original New Drug Application Approvals by US FDA (16-31 October 2024)

New drug applications approved by US FDA as of 16-31 October 2024 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-31 October 2024)

Vitamin K2 supplementation eases leg cramps in seniors

Daily supplementation with vitamin K2 helps minimize the frequency, intensity, and duration of nocturnal leg cramps in older adults while having a good safety profile, as shown in a study.

Vitamin K2 supplementation eases leg cramps in seniors

Black coffee helps prevent metabolic syndrome in women

Drinking 2 to 3 cups of black coffee daily appears protective against metabolic syndrome (MetS) in women, potentially due to its positive impact on high-density lipoprotein cholesterol (HDL-C) and triglycerides, suggests a Korea study.

Black coffee helps prevent metabolic syndrome in women

Modified CXI predicts survival in CRC after surgery

The modified cachexia index (mCXI) is effective in predicting the survival outcomes in patients with colorectal cancer (CRC) following radical surgery, reports a study.

Modified CXI predicts survival in CRC after surgery

06 Nov 2024

Is rapid-rate oxaliplatin safer than standard infusion?

Rapid infusion of oxaliplatin appears to have minimal treatment modifications relative to standard administration but may lead to a higher incidence of peripheral neuropathy (PN), according to a study.

Is rapid-rate oxaliplatin safer than standard infusion?

Hyperuricaemia linked to short-term readmission, mortality risk in HF

For patients with heart failure (HF), hyperuricaemia is a risk factor for an increase in the risk of short-term hospital readmission and mortality, as reported in a retrospective study.

Hyperuricaemia linked to short-term readmission, mortality risk in HF

Mitral TEER clips hold benefits at 1 year in patients with atrial SMR

An analysis of the EXPANDed patient-level pooled cohort presented at HFSA 2024 demonstrates clinical benefits in patients with atrial SMR at 1 year following a mitral TEER procedure using newer-generation clip devices. These included a significant reduction in MR and substantial improvements in PROs

Mitral TEER clips hold benefits at 1 year in patients with atrial SMR

Increased risk of inflammatory CNS diseases following anti-TNF therapy for autoimmune diseases

Compared with conventional therapies, exposure to tumour necrosis factor (TNF) inhibitors is associated with increased risk of inflammatory central nervous system (CNS) diseases, irrespective of background autoimmune disease or TNF inhibitor type, a recent meta-analysis has found.

Increased risk of inflammatory CNS diseases following anti-TNF therapy for autoimmune diseases