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Treatment de-escalation safe in patients with ERBB2-positive early breast cancer and high TILs
De-escalation of chemotherapy dose and trastuzumab duration may not increase the risk of distant relapse or death in patients with ERBB2-positive (also referred to as HER2-positive) early breast cancer and tumour infiltrating lymphocyte (TIL) levels of ≥20 percent, according to a 10-year analysis of the phase III ShortHER trial.

‘Sandwich’ sequencing of adjuvant chemoradiation tied to less toxicity in advanced endometrial cancer
Survival and clinical [Disease Link 9] outcomes in patients with advanced stage [Disease Link 10] endometrial cancer are [Disease Link 11] comparable among the different sequences of adjuvant chemotherapy and radiation therapy, a recent study has shown. However, “sandwich” therapy results in less chronic toxicity, which provides an opportunity for a better quality of life in survivorship.

More prostate cancers caught with transperineal vs transrectal biopsy
When sampling prostate tissue using ultrasound guidance and local anaesthesia, going by the transperineal (LATP) approach results in greater detection of clinically significant prostate cancers relative to the transrectal (TRUS) approach, as shown in the TRANSLATE trial.






