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Waning immunity against COVID-19 reinfections: Lessons from Singapore cohort study

06 Jul 2023

A retrospective national cohort study in Singapore assessed hybrid immunity from previous infection and monovalent vaccination against medically attended symptomatic BA.4, BA.5, and XBB reinfections.

This study highlights the immune evasiveness of the XBB variants. All human viruses adapt to become more transmissible, more immune evasive, and less virulent over time, and SARS-CoV-2 is no exception.

Waning immunity against COVID-19 reinfections: Lessons from Singapore cohort study

06 Jul 2023

Novel antibiotics in the management of multidrug-resistant organisms: Real-world evidence

05 Jul 2023 by

Antimicrobial resistance is a global crisis. In 2019, antimicrobial-resistant bacterial pathogens directly caused 1.27 million deaths worldwide. [Lancet 2022;399:629-655] In particular, carbapenem-resistant gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae and carbapenem-resistant Acinetobacter baumannii cause infections that are particularly difficult to treat. This was the main focus of the Pfizer-organized Meet-the-expert session with Professor Yehuda Carmeli, Professor of Medicine at Sackler Medical School, Tel Aviv University, and Founder and Head of Israeli National Institute for Antibiotic Resistance and Infection Control, Tel Aviv Medical Center, Israel. Dr Lee Tau Hong, infectious disease physician at Mount Elizabeth Hospital, Singapore, chaired the session.

Novel antibiotics in the management of multidrug-resistant organisms: Real-world evidence

05 Jul 2023

Healthy diet tied to improved physical fitness

03 Jul 2023 by

A recent study found an association between a healthy diet and greater physical fitness in middle-aged adults.

Healthy diet tied to improved physical fitness

03 Jul 2023

COVID outcomes worse in polluted cities

01 Jul 2023 by

More evidence suggests that people exposed to more air pollution during the pandemic are at greater risk for COVID-19 infection, hospitalization, and death, but the exact mechanism behind the link is unknown.

COVID outcomes worse in polluted cities

01 Jul 2023

DOACs as good as LMWH for recurrent VTE prevention in cancer patients

29 Jun 2023

For patients with cancer who have recurrent venous thromboembolism (VTE), direct oral anticoagulants (DOACs) compare favourably with low-molecular-weight heparin (LMWH) in terms of recurrence prevention, according to a study.

DOACs as good as LMWH for recurrent VTE prevention in cancer patients

29 Jun 2023

Hypertension tied to weakened ventilatory efficiency

27 Jun 2023

Hypertensive individuals without a diagnosis of heart failure appear to have impaired ventilatory efficiency, which reflects an abnormal physiological response to exercise, according to a study.

Hypertension tied to weakened ventilatory efficiency

27 Jun 2023

Gliosis may explain depressive or cognitive symptoms after COVID

22 Jun 2023 by

Patients with persistent depressive or cognitive symptoms after an acute SARS-CoV-2 infection have elevated gliosis – a secondary event to brain injury – and inflammation as shown in a case-control study.

Gliosis may explain depressive or cognitive symptoms after COVID

22 Jun 2023

COVID-19 oral antivirals reduce hospitalization and inpatient progression in nursing home residents

21 Jun 2023 by

A territory-wide, retrospective cohort study in Hong Kong has shown that molnupiravir and nirmatrelvir/ritonavir are effective in reducing the risks of hospitalization and inpatient disease progression among older patients residing in nursing homes.

COVID-19 oral antivirals reduce hospitalization and inpatient progression in nursing home residents

21 Jun 2023

Updated CodeBreak 200 analyses boost sotorasib role in KRASG12C-mutant NSCLC

19 Jun 2023 by

In the PRO analyses of the phase III CodeBreak 200 trial, the first-in-class KRAS^G12C inhibitor sotorasib improved quality of life (QoL) of patients with pretreated KRAS^G12C-mutated advanced non-small-cell lung cancer (NSCLC) compared with docetaxel.

Updated CodeBreak 200 analyses boost sotorasib role in KRASG12C-mutant NSCLC

19 Jun 2023

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

16 Jun 2023

Antifibrotic treatment appears to put brakes on the decline of lung function, as evidenced by forced vital capacity (FVC) measurements, in patients with interstitial lung disease (ILD) related to connective tissue disease (CTD) or rheumatoid arthritis (RA), according to a study.

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

16 Jun 2023

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Waning immunity against COVID-19 reinfections: Lessons from Singapore cohort study

Waning immunity against COVID-19 reinfections: Lessons from Singapore cohort study

Novel antibiotics in the management of multidrug-resistant organisms: Real-world evidence

Novel antibiotics in the management of multidrug-resistant organisms: Real-world evidence

Healthy diet tied to improved physical fitness

Healthy diet tied to improved physical fitness

COVID outcomes worse in polluted cities

COVID outcomes worse in polluted cities

DOACs as good as LMWH for recurrent VTE prevention in cancer patients

DOACs as good as LMWH for recurrent VTE prevention in cancer patients

Hypertension tied to weakened ventilatory efficiency

Hypertension tied to weakened ventilatory efficiency

Gliosis may explain depressive or cognitive symptoms after COVID

Gliosis may explain depressive or cognitive symptoms after COVID

COVID-19 oral antivirals reduce hospitalization and inpatient progression in nursing home residents

COVID-19 oral antivirals reduce hospitalization and inpatient progression in nursing home residents

Updated CodeBreak 200 analyses boost sotorasib role in KRASG12C-mutant NSCLC

Updated CodeBreak 200 analyses boost sotorasib role in KRASG12C-mutant NSCLC

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

Hint of benefit with antifibrotic treatment seen for interstitial lung disease