Atopic Dermatitis Disease Summary

Overview

Atopic dermatitis is a kind of dermatitis that has specific characteristics that you can know more in the Introduction section.

Atopic dermatitis is one of the most common dermatological diseases affecting millions worldwide. It can affect both children and adults. More information about the prevalence of this disease in the Epidemiology section.

There are many causes of atopic dermatitis. The Etiology section enumerated these causes. The Pathophysiology section discussed the development of this skin disease.

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History and Physical Examination

Among 34 countries, it has been found that pain is the second most common symptom after pruritus. To know more, see the Clinical Presentation section.

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Diagnosis

In order to diagnose atopic dermatitis, the Hanifin and Rajka criteria in the Diagnostic Criteria section is used. In this section you will also learn how to assess the disease severity.

The Laboratory Tests and Ancillaries section discuss what tests can be done to help with the diagnosis of atopic dermatitis.

There are several diseases that can mimic atopic dermatitis and the Differential Diagnosis section has enumerated them.

Management

One of the goals of therapy is to reduce the symptoms to know more about the goals of therapy. See the Principles of Therapy section for further details.

Various topical and systemic therapies are recommended for the treatment of atopic dermatitis, such as corticosteroids, calcineurin inhibitors, phosphodiesterase type-4 (PDE-4) inhibitors, immunosuppressants, etc.  The Pharmacological Therapy section contains a more extensive discussion on these treatment options.

There are Lifestyle Modifications (eg avoidance of trigger factors, skin care) and preventive measures that can be done in order to manage atopic dermatitis. These are discussed in the Prevention and Lifestyle Modifications sections.

Educating the patient or caregiver about the disease is also an important aspect in the management of atopic dermatitis. Refer to the Patient Education section for further details.  

The sections of Other Therapy and Proactive Therapy discusses about the available options for the management of atopic dermatitis such as wet wrap therapy, phototherapy and immunoadsorption.

FAQ

Q: What are the diagnostic criteria for Atopic Dermatitis in clinical practice?
A: Diagnosis of Atopic Dermatitis is based on patient history, cutaneous findings (atopic stigmata), and physical examination. The Hanifin & Rajka criteria require at least 3 major features (pruritus, typical morphology/distribution, chronic or relapsing dermatitis, personal/family history of atopy) and at least 3 minor features (e.g., cheilitis, hand/foot dermatitis, ichthyosis, xerosis, increased serum IgE, early onset, etc.). 
Q: How should initial assessment and identification of exacerbating factors in Atopic Dermatitis be approached? A: Initial assessment involves a thorough history and physical exam, focusing on exacerbating factors such as aeroallergens, foods, infections, irritating chemicals, emotional stress, and extreme temperatures. Identifying these can help tailor management and patient education. 
Q: What are the key non-pharmacological management strategies for Atopic Dermatitis?
A: Non-pharmacological therapy includes patient/caregiver education on the chronic nature of the disease, proper skin care (bathing, hydration, liberal use of emollients), stress-reduction techniques, and behavioral therapy to reduce scratching. Emphasis is placed on adherence to therapy and realistic expectations (control, not cure). Lifestyle modifications should be included and skin care
Q: What is the recommended approach to topical therapy in Atopic Dermatitis?
A: Topical corticosteroids should be applied 10–15 minutes after emollients, targeting only affected areas. Emollients should be used liberally and frequently, even in the absence of symptoms. Proper instruction reduces disease severity and corticosteroid use. 
Q: How can pharmacists and doctors address corticosteroid phobia and improve adherence in Atopic Dermatitis management?
A: Address concerns about corticosteroid side effects by educating patients/caregivers on correct application, the importance of compliance, and the low risk of adverse effects with proper use. This improves adherence and clinical outcomes.