Diabetic Ketoacidosis & Hyperosmolar Hyperglycemic State Disease Summary

Last updated: 29 October 2024

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Overview

The definitions of diabetic ketoacidosis and hyperosmolar hyperglycemic state are in the Introduction section.

The Epidemiology section discusses the incidence of diabetic ketoacidosis and hyperosmolar hyperglycemic state as causes of hospital admissions in patients with diabetes.

Both diabetic ketoacidosis and hyperosmolar hyperglycemic state arise from a setting of relative or absolute insulin deficiency combined with an increase in circulating counterregulatory hormones such as glucagon, cortisol, growth hormone, and catecholamines. The Pathophysiology section further elaborates on these mechanisms.

Precipitating risk factors for developing diabetic ketoacidosis and hyperosmolar hyperglycemic state are enumerated in the Risk Factors section.

The different types of diabetic ketoacidosis and hyperosmolar hyperglycemic state are enumerated and described in the Classification section. 

History and Physical Examination

Vital symptoms to elicit in the patient’s history is in the History section. During Physical Examination, symptoms of altered mental status are necessary to be identified. These symptoms are mentioned in this section.

Diagnosis

Parameters to be considered in the diagnosis of diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults and children are enumerated in the Diagnosis or Diagnostic Criteria section.

Laboratory Tests and Ancillaries section enumerate the tests that can be performed in assessing and evaluating a diabetic patient suspected to have diabetic ketoacidosis and/or hyperosmolar hyperglycemic state.

Other diseases that can cause similar symptoms that should be ruled out are in the Differential Diagnosis section.

Management

Diabetic ketoacidosis and hyperosmolar hyperglycemic state are best managed in the intensive care unit.

Drugs that can be considered in the management of diabetic ketoacidosis and hyperosmolar hyperglycemic state are discussed in the Pharmacological Therapy section. Some of these include IV fluids, Insulin and Somatostatin.

Educating the patient regarding the disease and what to do when diabetic ketoacidosis and/or hyperosmolar hyperglycemic state presents in a patient is essential and details of these are discussed in the Nonpharmacological section.

The Monitoring section explains methods in assessing the effect of management to the patient.